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The trial is currently in the recruitment phase. (Recruitment began on 20 November 2012, Expected to finish on November 2015).

Sung-Ji Park, Jin Joo Park contributed equally to this work.

Coronary CT angiography

Clinical Events Adjudication Committee

3’5’-Guanosine monophosphate

Cardiac magnetic resonance image

Data and Safety Monitoring Board

Electrocardiography

Magnetic resonance image

Microvascular angina

Nitric oxide

Phosphodiesterase

Phosphodiesterase-5-inhibitor

Transthoracic echocardiography

Serious adverse events

Saturation-recovery steady-state free precession

Unanticipated device effects

Quality of life.

Acknowledgements

The authors would like to acknowledge research nurse Eun-Young Oh and Min-Hwa Kim who contribute to the project implantation and data collection.

13063_2014_2208_MOESM1_ESM.tif Authors’ original file for figure 1
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Authors’ original file for figure 2
13063_2014_2208_MOESM3_ESM.tiff Authors’ original file for figure 3

The authors declare that they have no competing interests.

SJ: conception and design of the trial, data acquisition, critical establishment and management of the whole database, manuscript writing and final approval of the manuscript. JJ: conception and design and of the trial, data acquisition, critical establishment/management of the whole database, manuscript writing and final approval of the manuscript. SY: design of the study, performed the statistical analysis, critical revision and final approval of the manuscript. SA: design of the study, performed the statistical analysis, critical revision and final approval of the manuscript. SM: design the MRI protocols, data acquisition, critical revision and final approval of the manuscript. EJ: data acquisition, design the MRI protocol, critical revision and final approval of the manuscript. SI: design the MRI protocols, critically revised the manuscript for important intellectual content and final approval of the manuscript. YH: design the MRI protocols, critically revised the manuscript for important intellectual content and final approval of the manuscript. DJ: conception, design of the trials, critically revised the manuscript for important intellectual content and final approval of the manuscript. All authors read manuscript and have given final approval of the version of the manuscript to be published.

Cardiovascular Imaging Center, Heart, Vascular, Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Korea
Cardiovascular Center, Seoul National University Bundang Hospital, Internal Medicine, College of Medicine, Seoul National University, Gyeonggi-do, South Korea
Department of Radiology, College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea
Medical Research Collaborating Center, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( sast cheap online official site for sale Jimmy Choo Lang Glitter Sandals o26mFHoto0
), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( outlet tumblr cheap with mastercard Céline Crocodile PointedToe Pumps free shipping countdown package FdJLH5JwpL
) applies to the data made available in this article, unless otherwise stated.

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Excerpta Medica database

Post-trial follow-up

Randomised controlled trial

Thank you to all corresponding trialists.

Funding

RLB has received funding from the Royal College of Surgeons of England Research Fellowship.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Authors’ contributions

RLB designed, carried out the systematic review including screening, data capture, data analysis, interpretation of results and wrote the paper. DE screened the papers from the search strategy and identified relevant papers including checking 10% of data from the extraction stage. NR assisted in the design of the search strategy and completed the search strategy. RB, LB assisted in the search strategy and in decisions relevant to the review. LB and RB assisted in drafting the review. AH assisted in the discussions of the review and drafting. All authors read and approved the final manuscript.

Ethics approval and consent to participate

Not applicable.

Consent for publication

RLB, DE, NR, AH, LB and RB consent for publication.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated.

Additional file 1: PRISMA Checklist. (DOCX 30kb)
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Search strategies. Key to operators used in Medline/Ovid: where .pt. is publication type, (?) represents any single character, (*) is a group of characters, .mp.is multi-purpose search, /is Medical Subject Headings (MeSH), exp. is explode subject heading, .sh. is subject heading, (““) is phrase search. Comments: all results were downloaded with all fields displayed and in a tab delimited format. This file was then opened in Excel. Duplicates were removed. The spreadsheet sort order was changed to Enrollment A–Z and studies with fewer than 1000 enrollees will be removed. (PDF 396kb)
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Trials with long-term follow-up excluded from final analysis. *open-label study investigating safety doses of intervention. Extension study of two previous RCTs (Philipp T et al. Clin Ther 2007; 29:563–80). (PDF 147kb)
Additional file 4: Risk of bias shown in each domain for an individual randomised controlled trial (RCT). Red indicates high risk, yellow indicates unsure and green indicates low risk. (PDF 173kb)
MRC Population Health Research Unit, Clinical Trial Service Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK
Bodleian Health Care Libraries, University of Oxford, Oxford, UK
Molecular and Clinical Sciences Research Institute, St George’s University of London, London, UK
Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
©The Author(s).2018

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