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The trial is currently in the recruitment phase. (Recruitment began on 20 November 2012, Expected to finish on November 2015).

Sung-Ji Park, Jin Joo Park contributed equally to this work.

Coronary CT angiography

Clinical Events Adjudication Committee

3’5’-Guanosine monophosphate

Cardiac magnetic resonance image

Data and Safety Monitoring Board

Electrocardiography

Magnetic resonance image

Microvascular angina

Nitric oxide

Phosphodiesterase

Phosphodiesterase-5-inhibitor

Transthoracic echocardiography

Serious adverse events

Saturation-recovery steady-state free precession

Unanticipated device effects

Quality of life.

Acknowledgements

The authors would like to acknowledge research nurse Eun-Young Oh and Min-Hwa Kim who contribute to the project implantation and data collection.

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Authors’ original file for figure 1
13063_2014_2208_MOESM2_ESM.tiff Authors’ original file for figure 2
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The authors declare that they have no competing interests.

SJ: conception and design of the trial, data acquisition, critical establishment and management of the whole database, manuscript writing and final approval of the manuscript. JJ: conception and design and of the trial, data acquisition, critical establishment/management of the whole database, manuscript writing and final approval of the manuscript. SY: design of the study, performed the statistical analysis, critical revision and final approval of the manuscript. SA: design of the study, performed the statistical analysis, critical revision and final approval of the manuscript. SM: design the MRI protocols, data acquisition, critical revision and final approval of the manuscript. EJ: data acquisition, design the MRI protocol, critical revision and final approval of the manuscript. SI: design the MRI protocols, critically revised the manuscript for important intellectual content and final approval of the manuscript. YH: design the MRI protocols, critically revised the manuscript for important intellectual content and final approval of the manuscript. DJ: conception, design of the trials, critically revised the manuscript for important intellectual content and final approval of the manuscript. All authors read manuscript and have given final approval of the version of the manuscript to be published.

Cardiovascular Imaging Center, Heart, Vascular, Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Gangnam-gu, Korea
Cardiovascular Center, Seoul National University Bundang Hospital, Internal Medicine, College of Medicine, Seoul National University, Gyeonggi-do, South Korea
Department of Radiology, College of Medicine, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea
Medical Research Collaborating Center, Seoul National University Bundang Hospital, Gyeonggi-do, South Korea

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( Christian Louboutin Maralena Strass PeepToe Pumps outlet shop offer KdKNVd
) applies to the data made available in this article, unless otherwise stated.

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Excerpta Medica database

Post-trial follow-up

Randomised controlled trial

Thank you to all corresponding trialists.

Funding

RLB has received funding from the Royal College of Surgeons of England Research Fellowship.

Availability of data and materials

The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.

Authors’ contributions

RLB designed, carried out the systematic review including screening, data capture, data analysis, interpretation of results and wrote the paper. DE screened the papers from the search strategy and identified relevant papers including checking 10% of data from the extraction stage. NR assisted in the design of the search strategy and completed the search strategy. RB, LB assisted in the search strategy and in decisions relevant to the review. LB and RB assisted in drafting the review. AH assisted in the discussions of the review and drafting. All authors read and approved the final manuscript.

Ethics approval and consent to participate

Not applicable.

Consent for publication

RLB, DE, NR, AH, LB and RB consent for publication.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/ ), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( http://creativecommons.org/publicdomain/zero/1.0/ ) applies to the data made available in this article, unless otherwise stated.

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PRISMA Checklist. (DOCX 30kb)
Additional file 2: Search strategies. Key to operators used in Medline/Ovid: where .pt. is publication type, (?) represents any single character, (*) is a group of characters, .mp.is multi-purpose search, /is Medical Subject Headings (MeSH), exp. is explode subject heading, .sh. is subject heading, (““) is phrase search. Comments: all results were downloaded with all fields displayed and in a tab delimited format. This file was then opened in Excel. Duplicates were removed. The spreadsheet sort order was changed to Enrollment A–Z and studies with fewer than 1000 enrollees will be removed. (PDF 396kb)
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Trials with long-term follow-up excluded from final analysis. *open-label study investigating safety doses of intervention. Extension study of two previous RCTs (Philipp T et al. Clin Ther 2007; 29:563–80). (PDF 147kb)
Additional file 4: Risk of bias shown in each domain for an individual randomised controlled trial (RCT). Red indicates high risk, yellow indicates unsure and green indicates low risk. (PDF 173kb)
MRC Population Health Research Unit, Clinical Trial Service Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK
Bodleian Health Care Libraries, University of Oxford, Oxford, UK
Molecular and Clinical Sciences Research Institute, St George’s University of London, London, UK
Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
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As Sheila Heen and Douglas Stone lay out in their book Thanks for the Feedback: The Science and Art of Receiving Feedback Well , feedback is hard to process because it forces us to grapple with two, sometimes conflicting, core human needs: The drive to learn and grow, which is inherently satisfying, and the drive to be accepted, respected, and loved the way we are now.

Individual sensitivity to feedback varies tremendously, and can be measured by your baseline happiness, how far you swing up or down in response to positive or negative feedback, and how long it takes you to return to your baseline. Whenever you begin working with someone new—a direct report, a client, a mentee—make an effort to learn about their feedback tendencies and preferences off the bat. This can be done via a quick and friendly chat, using hypothetical situations before real issues arise. For example: “If I notice you offended a colleague in a meeting, would you prefer I let you know mid-meeting, directly after the meeting, or later via an email so you have time to process?”

You might even encourageeveryone on your team to write a user manual in which they offer an explicit description of their values, tendencies, and preferred methods for working with others. By personalizing your feedback relationships, you guardrail yourself from giving ineffective, potentially offensive critique, and prime your team for ongoing success.

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It’s important to remember that no one wins when we avoid difficult conversations, and it’s dangerous to delay critical feedback. A good rule of thumb is not waiting more than 24 hours, as the specific details will start to fade away and both the feedback giver and receiver will selectively remember what transpired.

Venture capitalist Ben Horowitz of Andreessen Horowitz views a CEO’s ability to give “ high-frequency feedback ” as a differentiating skill. “You should have an opinion on every forecast, every product plan, every presentation and even every comment,” he has opined. This continuous process will have the added benefit of depersonalizing feedback and creating an environment in which people will feel comfortable discussing bad news.

Horowitz warns against delivering the “shit sandwich” (that is, sandwiching negative feedback between two “slices” of praise) and has a simple rule about where not to give feedback: “Don’t clown people in front of their peers.”

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The tension between giving transparent feedback and caring for your direct reports is what makes giving good feedback so difficult. Kim Scott, a former executive at Google and Apple and author of Radical Candor: Be a Kickass Boss without Losing your Humanity , created a simple 2×2 matrix to navigate this complexity.

Valve, which owns the largest online PC gaming store in the world, recently expanded its Link service from streaming a game from a high-end PC to a low-end one in a person’s house, to include the ability to stream games to a smartphone.

“There are quite a few people that are working on streaming, like Nvidia,” Guillemot said. “So, we think it’s a trend and that it will continue to evolve. Eventually, the technology will improve dramatically, which will allow us to have a very smooth experience in the big cities of the world.”

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Nintendo for its part doesn’t see its consoles going anywhere anytime soon. The company is just a year into the incredible success of the Nintendo Switch – a hybrid console that can be played on the go or off of a television. So in some ways, it’s following the same philosophy of ubiquitous gaming, but on its own platform.

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“Microsoft has a long history as a leader in the world of gaming,” Phil Spencer, e xecutive vice president of gaming for Microsoft, told Variety. That history starts back in the early days of Windows with titles like “Minesweeper” and “Solitaire,” and then advanced with the company’s push into consoles with the original and then its support of online console gaming, streaming and game services. In 2013, Microsoft launched its latest console, the cheap sale best wholesale footaction online Valentino Satin LaceUp Sandals YmxT7Cb
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Our focus right now is asking the question, ‘What can Microsoft do for gaming?’ instead of simply how to stack up against the competition. It’s why we look at expanding the audience with Xbox Adaptive Controller, or how we make sure games can be multi-generational with projects like backward compatibility. I care less that people play Minecraft on an Xbox One , but that people can play Minecraft no matter what console or device they have in front of them.”

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